Titrate the dosage of acetaminophen and codeine phosphate tablets gradually in geriatric people and routinely reevaluate the individual for indications of central anxious system depression (see WARNINGS).
You shouldn't use codeine When you've got critical respiratory difficulties, a blockage with your abdomen or intestines, or Repeated bronchial asthma assaults or hyperventilation.
Even though the threat of habit in any specific is mysterious, it could happen in individuals appropriately prescribed acetaminophen and codeine phosphate tablets. Addiction can come about at proposed dosages and if the drug is misused or abused.
Acetaminophen and codeine phosphate tablets ought to be prescribed only by Health care gurus that are proficient about the usage of opioids and the way to mitigate the affiliated pitfalls.
Generally consult your Health care supplier to make sure the data shown on this page relates to your personal situation.
Assess Each individual affected person’s danger for opioid habit, abuse, or misuse ahead of prescribing acetaminophen and codeine phosphate tablets, and reassess all patients acquiring acetaminophen and codeine phosphate tablets for the development of these behaviors and situations. Pitfalls are amplified in clients with a personal or relatives record of compound abuse (including drug or Alcoholic beverages abuse or dependancy) or psychological health issues (e.g., significant melancholy). The probable for these dangers shouldn't, even so, reduce the appropriate management of ache in almost any supplied affected individual.
Inform sufferers that opioids could bring about a scarce but perhaps lifetime-threatening ailment resulting from concomitant administration of serotonergic medicines. Warn clients of your symptoms and signs of serotonin syndrome and to seek health-related consideration at once if signs and symptoms build.
Reserve concomitant prescribing of acetaminophen and codeine phosphate tablets and benzodiazepines or other CNS depressants to be used in individuals for whom alternate therapy selections are inadequate (see PRECAUTIONS, Drug Interactions).
Use the bottom productive dosage for your shortest period of time in step with individual patient procedure targets [see Warnings]. Because the possibility of overdose will increase as opioid doses enhance, reserve titration to larger doses of acetaminophen and codeine phosphate tablets for patients in whom decrease doses are insufficiently efficient As well as in whom the envisioned advantages of working with a greater dose opioid Plainly outweigh the significant threats.
Suggest both equally individuals and caregivers with regard to the hazards of respiratory despair and sedation when acetaminophen and codeine phosphate tablets are utilized with benzodiazepines or other CNS depressants (like Alcoholic beverages and illicit medicines). Advise sufferers to not travel or function significant machinery right up until the consequences of concomitant use from the benzodiazepine or other CNS more info depressant are identified.
If a CYP3A4 inducer is discontinued, think about acetaminophen and codeine phosphate tablets dosage reduction and evaluate people at Repeated intervals for signs of respiratory despair and sedation.
Use with warning; start with decreased doses or with lengthier dosing intervals and titrate slowly and gradually while meticulously checking for side effects.
Recommend patients and caregivers that when medicines are not wanted, they should be disposed of promptly. Inform sufferers that click here drugs consider-back again selections are the preferred method to safely get more info and securely eliminate most kinds of unneeded medicines.
Other pain relievers click here (for instance naproxen, ibuprofen) may be prescribed using this medication. Inquire more info your health practitioner or pharmacist about working with this merchandise securely with other medicines.